Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide

Y Zhu, Q Li, H Jiang - Apmis, 2020 - Wiley Online Library
The increasing prevalence of cardiovascular diseases cannot adequately be explained by
traditional risk factors. Recently, accumulating evidence has suggested that gut microbiota …

Trimethylamine N‐oxide generated by the gut microbiota is associated with vascular inflammation: new insights into atherosclerosis

Y Liu, M Dai - Mediators of inflammation, 2020 - Wiley Online Library
Trimethylamine N‐oxide (TMAO) is a biologically active molecule generated by the gut
microbiota. Accumulating evidences have indicated a close association between high …

[HTML][HTML] Gut microbiota-derived TMAO: a causal factor promoting atherosclerotic cardiovascular disease?

M Canyelles, C Borràs, N Rotllan, M Tondo… - International journal of …, 2023 - mdpi.com
Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut
microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated …

[HTML][HTML] Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic …

S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

Interaction between gut microbiome and cardiovascular disease

J Peng, X Xiao, M Hu, X Zhang - Life Sciences, 2018 - Elsevier
Traditional cardiovascular risk factors do not underlie all incidence of cardiovascular
disease. In recent years, accumulating evidence has demonstrated that gut microbiota and …

[HTML][HTML] The contributory role of gut microbiota in cardiovascular disease

WHW Tang, SL Hazen - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Our group recently discovered that certain dietary nutrients possessing a trimethylamine
(TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the …

[HTML][HTML] The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

J Zhen, Z Zhou, M He, HX Han, EH Lv… - Frontiers in …, 2023 - frontiersin.org
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

WHW Tang, SL Hazen - Translational Research, 2017 - Elsevier
There is increasing appreciation that changes in microbiome composition and function can
promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites …

[HTML][HTML] Gut-derived metabolite, trimethylamine-N-oxide (TMAO) in cardio-metabolic diseases: detection, mechanism, and potential therapeutics

M Shanmugham, S Bellanger, CH Leo - Pharmaceuticals, 2023 - mdpi.com
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …

Gut microbiota and atherosclerosis

DY Li, WHW Tang - Current atherosclerosis reports, 2017 - Springer
Abstract Purpose of Review Studies in microbiota-mediated health risks have gained
traction in recent years since the compilation of the Human Microbiome Project. No longer …