Interest in the involvement of cell proliferation in carcinogenesis is focusing on discerning
precisely the role or roles this phenomenon plays [l]. The specific aim of this communication …

Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired
the ability to divide more rapidly than its normal counterparts (Nowell, PC (1976) Science …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

It is not surprising that cancer, a kind of derangement of development, hijacks DNA
methylation, which is necessary for normal mammalian embryogenesis. Both decreases and …

Abnormalities of genomic methylation patterns have been attributed a role in carcinogenesis
since the early 1980s, when large-scale demethylation of the genome was thought be an …

Cancer is often viewed as a genetic process in which the developing cancer cell acquires
successive mutational lesions that each provide the cell with a growth or survival advantage …

This paper examines the relationship between DNA mutagenic lesions, DNA methylation
and the involvement of these changes in the process of carcinogenesis. Many types of DNA …

In contrast to earlier views that there was much compartmentalization of the types of
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

It is frequently assumed that DNA-damaging agents are carcinogenic because they induce
mutations. However, another strong possibility is that the damage leads to heritable changes …