DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

It is frequently assumed that DNA-damaging agents are carcinogenic because they induce
mutations. However, another strong possibility is that the damage leads to heritable changes …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

The main thrusts of the arguments that aberrant DNA methylation is involved in the
generation of tumor heterogeneity and progression can be summarized as follows. The …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

It has been proposed that tumor suppressor genes can be silenced by ectopic de novo
methylation during tumor progression and that this epigenetic silencing is an alternative to …

DNA methylation is a significant regulator of gene expression, and its role in carcinogenesis
recently has been a subject of remarkable interest. The aim of this review is to analyze the …

The total genomic DNA methylation, ie, the percentage of methylated cytosines, was
measured in 20 cell lines derived from different types of human tumors. The measurements …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …