Epigenetic alterations, represented by aberrant DNA methylation, are deeply involved in
human cancers. In gastric cancers, tumor-suppressor genes are inactivated more frequently …

DNA methylation appears to play an important role in both physiological and experimentally
modified gene expression, and alterations in DNA methylation have been described in …

DNA methylation is a mechanism for changing the base sequence of DNA without altering
its coding function. As a heritable, yet reversible, epigenetic change, it has the potential of …

Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine
residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a …

The development of cancer with chemicals is a multistep process involving initiation,
promotion, and progression of tumor cells. Most experiments in recent years have been …

Epigenetics describes the study of stable, reversible alterations to the genome that affect
gene expression and genome function, the most studied mechanisms are DNA methylation …

Precise and deliberate observations on tumors stand true for decades, and then meet
mechanistic explanations. The presence of genetic alterations in tumors is now widely …

Epigenetic modifications include DNA methylation and covalent modification of histones.
These alterations are reversible but very stable and exert a significant impact on the …

An imbalance of DNA methylation, involving widespread hypomethylation, regional
hypermethylation and increased cellular capacity for methylation, is characteristic of human …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …