Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Understanding the mechanisms involved in the regulation of gene expression in eukaryotic
organisms is one of the major challenges facing the modern molecular biologist. Despite …

There is strong evidence that DNA methylation is not a neutral bystander in carcinogenesis,
but actively contributes to the process. Methylation of cytosine is known to promote mutation …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

Whereas accepted models of tumorigenesis exist for genetic lesions, the timing of epigenetic
alterations in cancer is not clearly understood. We have analyzed the profile of aberrations …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

The status of DNA methylatlon, as measured by the 5-methylcytosine content of nuclear
DNA, was examined in normal livers and in chemically induced or spontaneous primary …

Methylation of DNA is known to be an important mechanism of gene regulation. A hallmark
of cancer is the deregulation of the DNA methylation machinery and aberrant DNA …

Cancer epigenetics is rapidly moving into a translational phase, and knowledge on how
aberrant DNA methylation is induced is becoming important. Aging, chronic inflammation …