DNA methylation plays an important role in the establishment and maintenance of the
program of gene expression. Tumor cells are characterized by a paradoxical alteration of …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

In many common cancers such as transitional cell carcinoma (TCC), specific genes are
hypermethylated, whereas overall DNA methylation is diminished. Genome‐wide DNA …

Epigenetics is the study of all mechanisms that regulate gene transcription and genome
stability that are maintained throughout the cell division, but do not include the DNA …

There is an abundant amount of information on the mechanisms of action of genotoxic
chemicals that act as carcinogens and the role that mutations play in carcinogenesis …

Site-specific methylation of the human c-myc oncogene was investigated in a set of cultured
human tumor cell lines and normal human fibroblast strains. As previously reported, all of …

DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …

The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …