DNA demethylation and carcinogenesis
NP Kisseljova, FL Kisseljov - Biochemistry (Moscow), 2005 - Springer
DNA methylation plays an important role in the establishment and maintenance of the
program of gene expression. Tumor cells are characterized by a paradoxical alteration of …
program of gene expression. Tumor cells are characterized by a paradoxical alteration of …
DNA methylation and cancer: ghosts and angels above the genes
Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …
development of new technologies in epigenomics have started to unravel the mechanisms …
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma
F Kimura, HH Seifert, AR Florl… - … journal of cancer, 2003 - Wiley Online Library
In many common cancers such as transitional cell carcinoma (TCC), specific genes are
hypermethylated, whereas overall DNA methylation is diminished. Genome‐wide DNA …
hypermethylated, whereas overall DNA methylation is diminished. Genome‐wide DNA …
Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research
N Shenker, JM Flanagan - British journal of cancer, 2012 - nature.com
Epigenetics is the study of all mechanisms that regulate gene transcription and genome
stability that are maintained throughout the cell division, but do not include the DNA …
stability that are maintained throughout the cell division, but do not include the DNA …
Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion
JL Counts, JI Goodman - Toxicology Letters, 1995 - Elsevier
There is an abundant amount of information on the mechanisms of action of genotoxic
chemicals that act as carcinogens and the role that mutations play in carcinogenesis …
chemicals that act as carcinogens and the role that mutations play in carcinogenesis …
Hypomethylation of DNA in Human Cancer Cells: A Site-Specific Change in the c-myc Oncogene
MSC Cheah, CD Wallace… - Journal of the National …, 1984 - academic.oup.com
Site-specific methylation of the human c-myc oncogene was investigated in a set of cultured
human tumor cell lines and normal human fibroblast strains. As previously reported, all of …
human tumor cell lines and normal human fibroblast strains. As previously reported, all of …
Reactivating the expression of methylation silenced genes in human cancer
AR Karpf, DA Jones - Oncogene, 2002 - nature.com
DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …
Cancer-epigenetics comes of age
The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …
DNA methylation and cancer
M Kulis, M Esteller - Advances in genetics, 2010 - Elsevier
DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …
In normal cells, it assures the proper regulation of gene expression and stable gene …
DNA methylation: past, present and future directions
KD Robertson, P A. Jones - Carcinogenesis, 2000 - academic.oup.com
DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …