DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

Carcinogenesis, a complex multifactorial process of the transformation of normal cells into
malignant cells, is characterized by many biologically significant and interdependent …

The methylation of cytosine at the 5′ position in the CpG dinucleotide palindrome is the
only known epigenetic modification in vertebrate DNA. Although 5-methylcytosine (5-mC) …

Epigenetic alterations such as DNA methylation have been implicated in the development
and progression of various cancers. DNA methylation consists of the reversible addition of a …

In summary, it is apparent that alterations in DNA methylation are a fundamental molecular
change associated with the neoplastic process and have important biologic implications for …

DNA methylation is essential for normal embryonic development. Distinctive genomic
methylation patterns must be formed and maintained with high fidelity to ensure the …

Cancer is ranked as one of the top killers in all human diseases and continues to have a
devastating effect on the population around the globe. Current research efforts are aiming to …

DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

Epigenetics now refers to the study or research field related to DNA methylation and histone
modifications. Historically, global DNA hypomethylation was first revealed in 1983, and, after …