We are in an era where the potential exists for deriving comprehensive profiles of DNA
alterations characterizing each form of human cancer. Such profiles would provide …

We propose a general model for neoplastic development which postulates that the loss of
methyl groups from 5-methylcytosines (5-mC) involved in the control of gene expression …

DNA methylation, chromatin structure, transcription, and cancer have traditionally been
studied as separate phenomena. Recent data provide now direct physical and functional …

Publisher Summary This chapter discusses DNA methylation in eukaryotic cells. DNA
methylation pattern undergoes discrete changes, especially during the process of …

DNA methylation is known to be abnormal in all forms of cancer, but it is not really
understood how this occurs and what is its role in tumorigenesis. In this review, we take a …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Cancer is an epigenetic disease at the same level that it can be considered a genetic
disease. In fact, epigenetic changes, particularly DNA methylation, are susceptible to …

The role of DNA methylation and recently discovered hydroxymethylation in the function of
the human epigenome is currently one of the hottest topics in the life sciences. Progress in …

Hypermethylation of tumor suppressor genes and other genes functionally important in the
neoplastic process is a recently recognized process. This epigenetic process is …

An obstacle to progress in understanding eukaryotic DNA methylation has been the lack of a
good genetic systemthe most favorable eukaryotes for genetic analysis (yeasts …