Changes in the genome which result in cancer promotion remain a complex interplay of
aberrant methylation in the setting of a multitude of epigenetic changes. The events leading …

Three basic approaches have been employed in the study of the effect of DNA methylation
of particular genes on their expression. One approach uses chemicals that cause …

Alterations of DNA methylation, which result in chromosomal instability and silencing of
tumor‐related genes, are among the most consistent epigenetic changes observed in …

In this review, we will provide a brief reminder of epigenetic phenomena in general, and
DNA methylation in particular. We will then underline the characteristics of the in vivo …

DNA methyltransferase is needed for normal development, perhaps because DNA
methylation plays a part in the control of gene activity. It is clear that the methylation of …

We have used a combination of genetics and pharmacology to assess the effects of reduced
DNA methyltransferase activity on ApcM~"-induced intestinal neoplasia in mice. A reduction …

Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

DNA methylation is one of the best-known epigenetic modifications in mammals. The
alteration of DNA methylation patterns has been found to be related to many diseases …

DNA methylation has come of age. For more than 40 years, it has been known that
eukaryotes tag their DNA by the covalent addition of a methyl group to cytosine residues; …