5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity
AI Bernstein, Y Lin, RC Street, L Lin… - Human molecular …, 2016 - academic.oup.com
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by
progressive deterioration of cognitive function. Pathogenesis of AD is incompletely …
progressive deterioration of cognitive function. Pathogenesis of AD is incompletely …
A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease
Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …
[HTML][HTML] Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease
L Shu, W Sun, L Li, Z Xu, L Lin, P Xie, H Shen, L Huang… - BMC genomics, 2016 - Springer
Background Alzheimer's disease (AD) is the most common form of neurodegenerative
disorder that leads to a decline in cognitive function. In AD, aggregates of amyloid β peptide …
disorder that leads to a decline in cognitive function. In AD, aggregates of amyloid β peptide …
[HTML][HTML] Alzheimer's disease-associated (hydroxy) methylomic changes in the brain and blood
R Lardenoije, JAY Roubroeks, E Pishva, M Leber… - Clinical …, 2019 - Springer
Abstract Background Late-onset Alzheimer's disease (AD) is a complex multifactorial
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …
Single-base resolution mapping of 5-hydroxymethylcytosine modifications in hippocampus of Alzheimer's disease subjects
EM Ellison, MA Bradley-Whitman, MA Lovell - Journal of Molecular …, 2017 - Springer
Epigenetic modifications to cytosine have been shown to regulate transcription in cancer,
embryonic development, and recently neurodegeneration. While cytosine methylation …
embryonic development, and recently neurodegeneration. While cytosine methylation …
DNA modifications and Alzheimer's disease
Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting millions of
people worldwide. While a number of studies have focused on identifying genetic variants …
people worldwide. While a number of studies have focused on identifying genetic variants …
[HTML][HTML] DNA methylation signature of human hippocampus in Alzheimer's disease is linked to neurogenesis
M Altuna, A Urdánoz-Casado… - Clinical …, 2019 - Springer
Background Drawing the epigenome landscape of Alzheimer's disease (AD) still remains a
challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD …
challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD …
Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease
Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder
that likely involves epigenetic factors. To better understand the epigenetic state associated …
that likely involves epigenetic factors. To better understand the epigenetic state associated …
Promoter DNA hypermethylation–implications for Alzheimer's disease
Recent methylome-wide association studies (MWAS) in humans have solidified the concept
that aberrant DNA methylation is associated with Alzheimer's disease (AD). We summarize …
that aberrant DNA methylation is associated with Alzheimer's disease (AD). We summarize …
Epigenetic signatures of methylated DNA cytosine in Alzheimer's disease
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common
untreatable form of dementia. Identifying molecular biomarkers that allow early detection …
untreatable form of dementia. Identifying molecular biomarkers that allow early detection …