Methylation of cytosines can mediate epigenetic gene silencing and is the only known DNA
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …

DNA methylation is an essential part of the epigenome chromatin modification network,
which also comprises several covalent histone protein post-translational modifications. All …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

Genetic, biochemical and cytological studies on DNA methylation in several eukaryotic
organisms have resulted in leaps of understanding in the past three years. Discoveries of …

DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

DNA and histone methylation are linked and subjected to mitotic inheritance in mammals.
Yet how methylation is propagated and maintained between successive cell divisions is not …

In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

DNA methylation was the first epigenetic modification discovered. Until recently,
comprehensive coverage of the composition and distribution of methylated cytosines across …