DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

The chemical modification of DNA bases plays a key role in epigenetic gene regulation.
While much attention has been focused on the classical epigenetic mark, 5-methylcytosine …

Recent advances have expanded our understanding of the processes underlying the
establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes …

Changes in cellular phenotypes and identities are fundamentally regulated by epigenetic
mechanisms including DNA methylation, post-translational histone modifications and …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

DNA methylation plays a pivotal role during development in mammals and is central to
transcriptional silencing. The DNA methyltransferases (DNMTs) are responsible for the …

DNA methylation is a biochemical process where a DNA base, usually cytosine, is
enzymatically methylated at the 5-carbon position. An epigenetic modification associated …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

DNA methylation is one of the principal epigenetic signals that participate in cell specific
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …