The discovery of avian cochlear hair cell regeneration in the late 1980s and the concurrent
development of new techniques in molecular and developmental biology generated a …

Loss of sensory hair cells is the leading cause of deafness in humans. The mammalian
cochlea cannot regenerate its complement of sensory hair cells. Thus at present, the only …

Deafness commonly results from a lesion of the sensory cells and/or of the neurons of the
auditory part of the inner ear. There are currently no treatments designed to halt or reverse …

Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower
vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is …

Hair cells in the mammalian inner ear convert sound into electrical signals that are relayed
to the nervous system by the chemical neurotransmitter glutamate. Electrical information …

Mechanosensory hair cells of the vertebrate cochlea offer an excellent developmental
system to study cell-fate specification, and to gain insight into the many human neurological …

Cochlear hair cells (HCs) are the mechanoreceptors of the auditory system, and because
these cells cannot be spontaneously regenerated in adult mammals, hearing loss due to HC …

We explore the changes in chromatin accessibility and transcriptional programs for cochlear
hair cell differentiation from postmitotic supporting cells using organoids from postnatal …

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair
cells are lost following an injury, no recovery could occur. However, during the first postnatal …

Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …