DNA methylation is a covalent modification of DNA that plays an important role in setting
gene expression programs during development. Recent evidence suggests that changes in …

Publisher Summary Deoxyribonucleic acid (DNA) methylation, a covalent modification of the
genome, is emerging as an important player in the regulation of gene expression. This …

Epigenetics refers to partially reversible, somatically inheritable, but DNA sequence-
independent traits that modulate gene expression, chromatin structure, and cell functions …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

DNA methylation is one of the most extensively studied, and one of the most stable, of all
epigenetic modifications. Two drugs that target DNA methyltransferase enzymes are …

Epigenetic regulation is essential to the well-being of developing as well as developed cells
by providing tissue-specific gene expression. DNA methylation on cytosine nucleotides is …

DNA methylation is a mammalian epigenetic mark that is involved in defining where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

DNA methylation is a critical component of gene regulation and plays an important role in
the development of cancer. Hypermethylation of tumor suppressor genes and silencing of …

There is overwhelming evidence that DNA methylation patterns are altered in cancer.
Methylation of CG-rich islands in regulatory regions of genes marks them for transcriptional …

DNA methylation is a major epigenetic mechanism that leads to inhibition of gene
transcription and is known to be involved in the pathogenesis of cancer. The effectors of …