For decades, DNA methylation at the 5 position of cytosine (5mC) catalyzed by DNA
methyltransferases (DNMTs) is a well-known epigenetic modification in mammalian …

ABSTRACT microRNAs (miRNAs) and DNA methylation are the 2 epigenetic modifications
that have emerged in recent years as the most critical players in the regulation of gene …

The pursuit of DNA demethylation has a colorful history, but it was not until 2009 that the
stars of this story, the Ten-eleven-translocation (Tet) family of proteins, were really identified …

Comprehensive Summary 5‐Methylcytosine (5mC) is a dynamic and reversible epigenetic
modification in genomic DNA of higher eukaryotes. It has been well‐established that the …

DNA methylation plays important roles in cell differentiation, embryonic development, host
adaptations to environmental factors, and pathogenesis through regulation of gene …

Mammalian cells contain copious amounts of RNA including both coding and noncoding
RNA (ncRNA). Generally the ncRNAs function to regulate gene expression at the …

Epigenetic modifications influence gene expression without alterations to the underlying
nucleic acid sequence. In addition to the well-known 5-methylcytosine (5mC), 5 …

DNA methylation is a stable yet reversible epigenetic modification that regulates gene
expression. New technologies have provided deep insights into the distribution and function …

DNA cytosine methylation (5-methylcytosine, 5mC) is the most important epigenetic mark in
higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA …

The mammalian DNA methylation landscape is established and maintained by the
combined activities of the two key epigenetic modifiers, DNA methyltransferases (DNMT) …