Anti-inflammatory microRNAs for treating inflammatory skin diseases

SC Yang, A Alalaiwe, ZC Lin, YC Lin, IA Aljuffali… - Biomolecules, 2022 - mdpi.com
Skin inflammation occurs due to immune dysregulation because of internal disorders,
infections, and allergic reactions. The inflammation of the skin is a major sign of chronic …

MiR‐744‐3p regulates keratinocyte proliferation and differentiation via targeting KLLN in psoriasis

C Wang, J Zong, Y Li, X Wang, W Du… - Experimental …, 2019 - Wiley Online Library
Psoriasis is a chronic inflammatory disease, and micro RNA s have been reported to
regulate the pathogenesis of psoriasis. Up‐regulated miR‐744‐3p level was identified to …

Decreased microRNA‐126 expression in psoriatic CD4+ T cells promotes T‐helper 17 cell differentiation and the formation of dermatitis in imiquimod‐induced …

R Wu, X Li, S Li, G Tang, S Zhang, Y Zhu… - The Journal of …, 2022 - Wiley Online Library
Psoriasis is a chronic inflammatory skin disease with multiple genetic backgrounds, whose
etiology and pathogenesis are still unclear. Complex T‐cell immune imbalance has been …

MicroRNA 429 regulates MMPs expression by modulating TIMP2 expression in colon cancer cells and inflammatory colitis

SH Han, JS Mo, KJ Yun, SC Chae - Genes & Genomics, 2024 - Springer
Background In a previous study, we found that the expression of microRNA 429 (MIR429)
was decreased in dextran sodium sulfate (DSS)-induced mouse colitis tissues. Objective In …

[HTML][HTML] MicroRNA‐143‐3p ameliorates collagen‐induced arthritis by polarizing naive CD4+ T cells into Treg cells

MY Shen, BP Jiang, MF Zhang, X Wang… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Background Rheumatoid arthritis (RA) is a persistent and systemic autoimmunity disease.
The abnormal differentiation of Treg cells is important in pathogenesis. Despite previous …

MicroRNA-143 inhibits IL-13-induced dysregulation of the epidermal barrier-related proteins in skin keratinocytes via targeting to IL-13Rα1

YP Zeng, GH Nguyen, HZ Jin - Molecular and cellular biochemistry, 2016 - Springer
Atopic dermatitis is a chronic inflammatory skin disease characterized by the dysregulation
of the epidermal barrier and the immune system. Interleukin (IL)-13, a key T helper 2 …

MicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis

X Yu, J An, Y Hua, Z Li, N Yan, W Fan, C Su - Pathology-Research and …, 2017 - Elsevier
MicroRNAs (miRNAs) are currently emerged as important regulators in psoriasis. Psoriasis
is characterized by hyperproliferation and impaired differentiation of keratinocytes in skin …

MicroRNAs: novel regulators in skin inflammation

E Sonkoly, M Ståhle, A Pivarcsi - Clinical and experimental …, 2008 - academic.oup.com
Compelling evidence indicates that microRNAs (miRNAs), short, non‐protein coding RNAs,
are critical for the development and survival of multicellular organisms. Recently, miRNAs …

MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS-stimulated murine macrophages by targeting NF-κB1 (p50)

K Zhang, F Song, X Lu, W Chen, C Huang… - Bioscience …, 2017 - portlandpress.com
Inflammation is the body's normal self-protection mechanism to eliminate pathogens and
resist pathogen invasion. The excessive inflammatory response may lead to inflammatory …

[HTML][HTML] Inhibition of miR-139-5p by topical JTXK gel promotes healing of Staphylococcus aureus-infected skin wounds

W Zhang, X Qu, Z Zhu, L Wang, Q Qi, P Zhou… - Cells & Development, 2021 - Elsevier
Background The inflammatory skin wound response is regulated by argonaute 2-bound
microRNAs (Ago2-miRNAs) such as miR-139-5p, which inhibit transcription of their target …