We investigated aberrant methylation in 101 prostate cancers (PCa) and 32 histologically
normal prostate tissues. We focused on genes largely in the apoptotic pathway. Methylation …

Background DNA methylation has been linked to genome regulation and dysregulation in
health and disease respectively, and methods for characterizing genomic DNA methylation …

Prostate cancer affects an increasing number of men worldwide and is a leading cause of
cancer-associated deaths. Beside genetic mutations, many epigenetic alterations including …

Prior studies have shown that the estrogen receptor (ER) gene is down-regulated in prostate
cancer, but the mechanism of its inactivation is not known. We hypothesize that inactivation …

Promoter methylation plays an important role in the inactivation of tumor suppressor genes
during tumorigenesis. We examined the methylation status of glutathione s-transferase Pi1 …

Background: The role of global DNA methylation in prostate cancer (PCa) remains largely
unknown. Our aim was to summarize evidence on the role of global DNA hypomethylation in …

Epigenetic modifications can affect the long‐term gene expression without any change in
nucleotide sequence of the DNA. Epigenetic processes intervene in the cell differentiation …

Early prostate cancer (PCa) is generally treatable and associated with good prognosis. After
a variable time, PCa evolves into a highly metastatic and treatment-refractory disease …

Cancer is a collection of very complex diseases that share many traits while differing in
many ways as well. This makes a universal cure difficult to attain, and it highlights the …

Purpose: Prostate cancer is a leading cause of cancer death among the aging male
population but the mechanism underlying this association is unclear. Aberrant methylation of …