Methylation of DNA plays an important role in organizing the genome into transcriptionally
active and inactive zones. Nickel compounds cause chromatin condensation and DNA …

A transgenic gpt+ Chinese hamster cell line (G12) was found to be susceptible to
carcinogenic nickel-induced inactivation of gpt expression without mutagenesis or deletion …

DNA methylation and histone modification promote changes in chromatin structure that may
affect gene expression in a heritable manner without directly altering the genome. As such …

Epigenetics refers to heritable patterns of gene expression that do not depend on alterations
of the genomic DNA sequence. Nickel compounds have demonstrated carcinogenicity …

On the basis of studies with carcinogenic nickel compounds, we propose a new model of
how epigenetic carcinogens might act. This model is based on the fact that nickel …

Nickel (Ni) compounds are potent carcinogens and can induce malignant transformation of
rodent and human cells. To uncover the molecular mechanisms of nickel sulfide (NiS) …

We have previously reported that carcinogenic nickel compounds decreased global histone
H4 acetylation and silenced the gpt transgene in G12 Chinese hamster cells. However, the …

Although carcinogenic metals have been known to disrupt a wide range of cellular
processes the precise mechanism by which they exert their carcinogenic effects is not …

A brief review of the molecular mechanisms of nickel carcinogenesis is presented. Molecular
mechanisms of nickel carcinogenesis are considered from the pointofview of nickelinduced …

This article considers the mechanism of nickel carcinogenesis, focusing primarily on the
epigenetic changes associated with exposure of cells to carcinogenic nickel compounds …