The past decade has seen an explosion of interest in the epigenetics of cancer, with an
increasing understanding that this form of genomic modification plays a critical role in …

Cancer is also an epigenetic disease. The main epigenetic modification in humans is DNA
methylation. Transformed cells undergo a dramatic change in their DNA methylation …

The DNA methylation profile of cancer cells is frequently characterized by global
hypomethylation and simultaneous hypermethylation of selected CpG island gene …

The term epigenetics defines a heritable alteration in gene expression without an
accompanying change in primary DNA sequence. Two major mechanisms that foster …

Cancer cells are associated with global hypomethylation but with focal hypermethylation of
specific gene promoters organized as CpG island. DNA methyltransferases, DNMT1 and 3 …

Leukaemogenesis is a multi-step process whereby a clonal population arises that has
undergone successive alterations to the genotype and the phenotype of the cells that make …

BACKGROUND AND OBJECTIVES: Methylation of DNA is a common epigenetic
modification that plays an important role in the control of gene expression in mammalian …

Background: Gene silencing through aberrant CpG island methylation is the most
extensively analyzed epigenetic event in human tumorigenesis and has huge diagnostic …

Background and objectives: aberrant promoter methylation targets CpG islands causing
gene silencing. We explored aberrant promoter methylation of genes potentially involved in …

Hypermethylation of CpG islands near gene promoter regions is associated with
transcriptional inactivation and represents an important mechanism of gene silencing in …