DNA methylation, the addition of a methyl group to the carbon-5 position of cytosine
residues, is the only common covalent modification of human DNA and occurs almost …

Human cancers frequently show altered patterns of DNA methylation, particularly at CpG
islands. These CpG islands are sequences of DNA rich in CpG dinucleotides and are often …

Cancer is an epigenetic disease at the same level that it can be considered a genetic
disease. In fact, epigenetic changes, particularly DNA methylation, are susceptible to …

The promoter region of the cyclin-dependent kinase inhibitor p15INK4B contains a CpG
island that is hypermethylated in many hematologic malignancies. To explore the …

Aberrant DNA methylation has been observed consistently in many human tumours, in
particular in the CpG islands of tumour suppressor genes, but the underlying mechanism of …

DNA methylation is a dynamic process influencing gene expression by altering either coding
or non-coding loci. Despite advances in treatment of Acute Lymphoblastic Leukemia (ALL); …

DNA methylation provides a major epigenetic code (besides histone modification) of the
lineage-and developmentspecific genes (such as regulators of differentiation in the …

Epigenetic abnormalities, such as aberrant methylation of CpG islands, are inherited over
cell divisions, and play important roles in carcinogenesis. Aberrant methylation of CpG …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

DNA methylation of CpG islands around gene transcription start sites results in gene
silencing and plays a role in leukemia pathophysiology. Its impact in leukemia progression …