CpG islands are associated with at least half of all cellular genes and are normally
methylation-free. Dense methylation of cytosine residues within islands causes strong and …

The DNA methylation pattern of a cell is exquisitely controlled during early development
resulting in distinct methylation patterns. The tight control of DNA methylation is released in …

DNA methylation has a role in the regulation of gene expression during normal mammalian
development but can also mediate epigenetic silencing of CpG island genes in cancer and …

Hypermethylation of CpG islands, an epigenetic event that is not accompanied by changes
in DNA sequence, represents an alternative mechanism to deletions or mutations to …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

Carcinogenesis is thought to occur through a combination of mutational and epimutational
events that disrupt key pathways regulating cellular growth and division. The DNA …

Most investigations on the role of DNA methylation in cancer have focused on epigenetic
changes associated with known tumor suppressor genes. This may have led to an …

A higher prevalence of epigenetic inactivation of tumor suppressor genes has been reported
in cancer cell line populations compared to primary cancer populations. Cancer-related …

A cancer develops when a cell acquires specific growth advantages through the stepwise
accumulation of heritable changes in gene function. Basically, this process is directed by …