Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

DNA methylation is important in the control of gene transcription and chromatin structure.
The complexities of this process are just beginning to be elucidated in relationship to other …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

One of the most fundamental questions in the control of gene expression in mammals is how
epigenetic methylation patterns of DNA and histones are established, erased, and …

Epigenetic information refers to heritable changes in gene function that are stable between
cell divisions but which is not a result of changes in the DNA sequence. Part of the …

DNA methylation inhibits gene expression in animal cells, probably by affecting chromatin
structure. Biochemical studies suggest that this process may be mediated by methyl-specific …

Mammalian genomes are compartmentalized into dense inactive chromatin that is
hypermethylated and active open chromatin that is hypomethylated. It is generally accepted …

Although the field of genetics has grown by leaps and bounds within the last decade due to
the completion and availability of the human genome sequence, transcriptional regulation …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …