It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in
mammalian genomes. Here we identify N 6-methyladenine as another form of DNA …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

The methylation of vertebrate DNA at the 5-position of∼ 3–10% of its cytosine residues
occurs in a sequence-specific and tissue-specific manner1–3 and has been implicated in …

Methylation at the 5′ position of cytosine in DNA has important roles in genome function
and is dynamically reprogrammed during early embryonic and germ cell development. The …

In mammalian cells, DNA methylation on the fifth position of cytosine (5mC) plays an
important role as an epigenetic mark. However, DNA methylation was considered to be …

hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell types
in mammals,,,,. 5hmC is generated by the TET family of Fe (II) and 2-oxoglutarate-dependent …

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …

DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …

Abstract DNA N 6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA
modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here …

ARE changes in DNA methylation patterns a cause or an effect of eukaryotic gene
expression? There are already many examples of an inverse correlation between the level …