DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell
differentiation. Until recently, it was still unclear how unmethylated regions in mammalian …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

In mammals, DNA methylation is a crucial epigenetic modification with key functions during
development. Cellular processes that are regulated by DNA methylation comprise X …

The past decade has witnessed rapid advances in our understanding of the biochemistry of
“epigenetics,” as exemplified by the articles in this minireview series. Epigenetics is usually …

Methylation of cytosines can mediate epigenetic gene silencing and is the only known DNA
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …

Epigenetic regulation is essential to the well-being of developing as well as developed cells
by providing tissue-specific gene expression. DNA methylation on cytosine nucleotides is …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

DNA methylation, the addition of a methyl group at the 5-position of cytosine (5-
methylcytosine, 5mC), is a major epigenetic modification in the genomes of many animals …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …