Background Epigenetic alterations are known contributors to cancer development and
aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are …

The tumor immune microenvironment (TIME), an immunosuppressive niche, plays a pivotal
role in contributing to the development, progression, and immune escape of various types of …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Epigenetic regulation of gene expression in cancer cells has been extensively studied in
recent decades, resulting in the FDA approval of multiple epigenetic agents for treating …

Epigenetic changes in oncogenes and tumor-suppressor genes contribute to
carcinogenesis. Understanding the epigenetic and genetic components of tumor immune …

The tumor immune microenvironment represents a sophisticated ecosystem where various
immune cell subtypes communicate with cancer cells and stromal cells. The dynamic …

The tumour microenvironment plays an instrumental role in cancer development,
progression and treatment response/resistance. Accumulating evidence is underscoring the …

In recent years, immunotherapy has become a hot spot in the treatment of tumors. As an
emerging treatment, it solves many problems in traditional cancer treatment and has now …

Epigenetic mechanisms are processes that affect gene expression and cellular functions
without involving changes in the DNA sequence. This abnormal or unstable expression of …

Background Epigenetic mechanisms regulate chromatin accessibility patterns that govern
interaction of transcription machinery with genes and their cis-regulatory elements …