Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …

Purpose: Aberrant promoter methylation and genomic instability occur frequently during
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown …

Background & Aims: The concept of a CpG island methylator phenotype (CIMP), especially
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …

Aberrant methylation of promoter region CpG islands is associated with transcriptional
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …

Background: The concept of CpG island methylator phenotype (CIMP) is not universally
accepted. Even if specific clinicopathological features have been associated with CIMP …

The CpG island methylator phenotype (CIMP) with widespread promoter CpG island
methylation is a phenotype in colorectal cancer, associated with microsatellite instability …

BACKGROUND &AIMS: Methylation of CpG islands is increasingly recognized as an
important event in colorectal carcinogenesis. We evaluated the extent of CpG island …

Background: Cigarette smoking has been associated with microsatellite instability in
sporadic colon cancer. Most microsatellite-unstable colon cancers have widespread …

Background: The CpG island methylator phenotype (CIMP), characterised by widespread
promoter methylation, is associated with microsatellite instability (MSI) and BRAF mutation in …

CpG islands are short stretches of CpG rich regions that are frequently associated with the
promoter region of genes. Aberrant methylation of CpG islands is one mechanism of …