Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations

F Fakhouri, L Roumenina, F Provot… - Journal of the …, 2010 - journals.lww.com
In contrast to pregnancy-associated thrombotic thrombocytopenic purpura, the pathogenesis
and presentation of pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) …

[HTML][HTML] A retrospective study of pregnancy-associated atypical hemolytic uremic syndrome

A Huerta, E Arjona, J Portoles, P Lopez-Sanchez… - Kidney international, 2018 - Elsevier
Pregnancy-associated atypical hemolytic uremic syndrome (aHUS) refers to the thrombotic
microangiopathy resulting from uncontrolled complement activation during pregnancy or the …

Pregnancy-triggered atypical hemolytic uremic syndrome (aHUS): a Global aHUS Registry analysis

F Fakhouri, M Scully, G Ardissino, I Al-Dakkak… - Journal of …, 2021 - Springer
Background Atypical hemolytic uremic syndrome (aHUS) is a rare disease in which
uncontrolled terminal complement activation leads to systemic thrombotic microangiopathy …

Maternal and fetal outcomes of pregnancies in women with atypical hemolytic uremic syndrome

M Gaggl, C Aigner, D Csuka, Á Szilágyi… - Journal of the …, 2018 - journals.lww.com
Atypical HUS (aHUS) is a disorder most commonly caused by inherited defects of the
alternative pathway of complement, or the proteins that regulate this pathway, and life …

Hemolytic uremic syndrome in pregnancy and postpartum

A Bruel, D Kavanagh, M Noris, Y Delmas… - Clinical Journal of the …, 2017 - journals.lww.com
Background Pregnancy is associated with various forms of thrombotic microangiopathy,
including hemolytic uremic syndrome. A previous small French study suggested that …

Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics

F Fakhouri, V Frémeaux-Bacchi - Nature Reviews Nephrology, 2021 - nature.com
Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …

[HTML][HTML] Pregnancy-associated atypical hemolytic uremic syndrome: a systematic review

M Gupta, S Govindappagari… - Obstetrics & Gynecology, 2020 - journals.lww.com
OBJECTIVE: To evaluate disease presentation, diagnosis, treatment, and clinical outcomes
in pregnancy-associated atypical hemolytic uremic syndrome (aHUS). DATA SOURCES: We …

Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome

S Feng, SJ Eyler, Y Zhang, T Maga… - Blood, The Journal …, 2013 - ashpublications.org
Complement dysregulation leads to atypical hemolytic uremic syndrome (aHUS), while
ADAMTS13 deficiency causes thrombotic thrombocytopenic purpura. We investigated …

A mechanistic approach to the diagnosis and management of atypical hemolytic uremic syndrome

HM Tsai - Transfusion Medicine Reviews, 2014 - Elsevier
Until recently, atypical hemolytic uremic syndrome (aHUS), conventionally defined in the
pediatric literature as a syndrome of the triad of renal failure, microangiopathic hemolytic …

Atypical hemolytic uremic syndrome in the setting of complement-amplifying conditions: case reports and a review of the evidence for treatment with eculizumab

A Asif, A Nayer, CS Haas - Journal of nephrology, 2017 - Springer
Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, progressive, life-threatening
form of thrombotic microangiopathy (TMA) predominantly caused by dysregulation of the …