Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone
Purpose Thyroid hormones are essential for the normal function of almost all human tissues,
and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3) …
and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3) …
Genome-wide association meta-analysis for total thyroid hormone levels in Croatian population
Thyroid hormones (THs) are key regulators of cellular growth, development, and
metabolism. The thyroid gland secretes two THs, thyroxine (T4) and triiodothyronine (T3) …
metabolism. The thyroid gland secretes two THs, thyroxine (T4) and triiodothyronine (T3) …
Three candidate SNPs show associations with thyroid-stimulating hormone in euthyroid subjects: Tehran thyroid study
A Zadeh-Vakili, L Najd-Hassan-Bonab… - Journal of Diabetes & …, 2024 - Springer
Objectives Previous studies have shown interindividual variation in free thyroxine (FT4)
serum levels and thyroid stimulating hormone (TSH) in healthy persons. Genetic factors …
serum levels and thyroid stimulating hormone (TSH) in healthy persons. Genetic factors …
The effects of common genetic variation in 96 genes involved in thyroid hormone regulation on TSH and FT4 concentrations
RBTM Sterenborg, TE Galesloot… - The Journal of …, 2022 - academic.oup.com
Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
RBTM Sterenborg, I Steinbrenner, Y Li… - Nature …, 2024 - nature.com
To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
Thyroid hormones play key roles in cellular growth, development and metabolism. Although
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
E Porcu, M Medici, G Pistis, CB Volpato… - PLoS …, 2013 - journals.plos.org
Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …
abnormalities in thyroid function lead to common endocrine disorders affecting …
A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents
TRH Nielsen, EVR Appel, M Svendstrup, JD Ohrt… - PLoS …, 2017 - journals.plos.org
Background Hypothyroidism is associated with obesity, and thyroid hormones are involved
in the regulation of body composition, including fat mass. Genome-wide association studies …
in the regulation of body composition, including fat mass. Genome-wide association studies …
A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels
M Medici, WM Van Der Deure… - European journal of …, 2011 - academic.oup.com
Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …
Phenomic impact of genetically-determined euthyroid function and molecular differences between thyroid disorders
Background: The thyroid plays a key role in development and homeostasis, but it has been
difficult to establish causality with diseases and phenotypic traits because of several …
difficult to establish causality with diseases and phenotypic traits because of several …