Gut microbiota-derived trimethylamine N-oxide is associated with the risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a …

Y Li, H Lu, J Guo, M Zhang, H Zheng, Y Liu… - Annals of …, 2023 - Taylor & Francis
Abstract Background Trimethylamine N-oxide (TMAO) derived from gut microbiota causes
kidney-heart damage in chronic kidney disease (CKD) patients. However, it is controversial …

[HTML][HTML] Gut microbiota-derived trimethylamine N-oxide and kidney function: a systematic review and meta-analysis

Y Zeng, M Guo, X Fang, F Teng, X Tan, X Li, M Wang… - Advances in …, 2021 - Elsevier
Elevated circulating trimethylamine N-oxide (TMAO) concentrations have been observed in
patients with chronic kidney disease (CKD). We aimed to systematically estimate and …

Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney …

WHW Tang, Z Wang, DJ Kennedy, Y Wu… - Circulation …, 2015 - Am Heart Assoc
Rationale: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary
choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney …

[HTML][HTML] Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

C Missailidis, J Hällqvist, AR Qureshi, P Barany… - PloS one, 2016 - journals.plos.org
Background The microbial metabolite Trimethylamine-N-oxide (TMAO) has been linked to
adverse cardiovascular outcome and mortality in the general population. Objective To …

[HTML][HTML] The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease

JAP Tomlinson, DC Wheeler - Kidney international, 2017 - Elsevier
Patients with chronic kidney disease (CKD) have an enhanced risk of cardiovascular (CV)
morbidity and mortality when compared with age-and gender-matched individuals with …

[HTML][HTML] Circulating trimethylamine-N-oxide and risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a systematic review and meta …

Z Zhou, H Jin, H Ju, M Sun, H Chen, L Li - Frontiers in Medicine, 2022 - frontiersin.org
Background Trimethylamine-N-oxide (TMAO) is expected to be a prognostic biomarker
among patients suffering from chronic kidney disease (CKD). However, investigations on the …

[HTML][HTML] TMAO is associated with mortality: impact of modestly impaired renal function

EG Gruppen, E Garcia, MA Connelly, EJ Jeyarajah… - Scientific reports, 2017 - nature.com
Abstract Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared
by the kidney and linked to renal function. We explored the relationship between TMAO and …

Trimethylamine N-oxide and risk of cardiovascular disease and mortality

C Kanitsoraphan, P Rattanawong, S Charoensri… - Current nutrition …, 2018 - Springer
Abstract Purpose of Review Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent
metabolite produced from choline and phosphatidylcholine. Trimethylamine N-oxide was …

The dietary source of trimethylamine N-oxide and clinical outcomes: an unexpected liaison

M Evans, L Dai, CM Avesani, K Kublickiene… - Clinical Kidney …, 2023 - academic.oup.com
The profile of gut microbiota can vary according to host genetic and dietary characteristics,
and be influenced by disease state and environmental stressors. The uremic dysbiosis …

[HTML][HTML] Elevation of trimethylamine-N-oxide in chronic kidney disease: contribution of decreased glomerular filtration rate

CC Pelletier, M Croyal, L Ene, A Aguesse… - Toxins, 2019 - mdpi.com
Gut microbiota-dependent Trimethylamine-N-oxide (TMAO) has been reported to be strongly
linked to renal function and to increased cardiovascular events in the general population …