CpG islands are normally methylation free in cells of the animal, even when the associated
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …

DNA methylation has been implicated in mammalian development. Transcription units
contain CpG islands, but expression of CpG island associated genes in normal tissues was …

Promoter region CpG island methylation is associated with tumor suppressor gene silencing
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are …

CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …

The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …

DNA methylation is the epigenetic modification, which introduces 5mC as fifth base onto
DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non …

Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …

Cancer cell lines are widely used in many types of cancer research, including studies aimed
at understanding DNA hypermethylation of gene promoters in cancer. Hypermethylation of …

Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

Aberrant methylation of promoter region CpG islands is associated with transcriptional
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …