Some of the key players of the methylation machinery are now in hand, offering an
opportunity to resolve contentious issues in the field of methylation. Perhaps the most …

DNA methylation is an important epigenetic mark involved in gene silencing, X chromosome
and transposon inactivation, genomic imprinting, and chromosome stability. Recently, it has …

ABSTRACT A murine transgene, HRD, is methylated only when carried in certain inbred
strain backgrounds. A locus on distal chromosome 4, Ssm1 (strain-specific modifier) …

Vertebrate DNA is methylated at a high proportion of cytosine residues in the sequence
CpG, and it has been suggested that the distribution of methylated and non-methylated …

During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

Abstract Development in mammals is accompanied by specific de novo and demethylation
events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

The methylation of CpG islands is often equated with transcriptional inactivity and there is
overwhelming evidence that this is the case for islands located in gene promoters. Such …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

DNA methyltransferases (DNMTs) comprise a family of proteins involved in the
establishment and maintenance of DNA methylation patterns in the mammalian genome …