Abstract Development in mammals is accompanied by specific de novo and demethylation
events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a …

Oct-3/4 is the earliest expressed transcription factor that is known to be crucial in murine pre-
implantation development. In this report we asked whether methylation participates in …

ABSTRACT A murine transgene, HRD, is methylated only when carried in certain inbred
strain backgrounds. A locus on distal chromosome 4, Ssm1 (strain-specific modifier) …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

The methylation of CpG islands is often equated with transcriptional inactivity and there is
overwhelming evidence that this is the case for islands located in gene promoters. Such …

Vertebrate DNA is methylated at a high proportion of cytosine residues in the sequence
CpG, and it has been suggested that the distribution of methylated and non-methylated …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

Publisher Summary This chapter discusses DNA methylation in eukaryotic cells. DNA
methylation pattern undergoes discrete changes, especially during the process of …