Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …

Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …

Thyroid hormones play key roles in cellular growth, development and metabolism. Although
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …

Single nucleotide polymorphisms (SNPs) in genes involved in thyroid hormone metabolism
may affect thyroid hormone bioactivity. We investigated the occurrence and possible effects …

Purpose Thyroid hormones are essential for the normal function of almost all human tissues,
and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3) …

Thyroid stimulating hormone (TSH) hormone levels are normally tightly regulated within an
individual; thus, relatively small variations may indicate thyroid disease. Genome-wide …

Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Background Hypothyroidism is associated with obesity, and thyroid hormones are involved
in the regulation of body composition, including fat mass. Genome-wide association studies …

Recent studies show that subtle variations in thyroid function, including subclinical thyroid
dysfunction, and even variation in thyroid function within the normal range, are associated …