A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels
M Medici, WM Van Der Deure… - European journal of …, 2011 - academic.oup.com
Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …
The effects of common genetic variation in 96 genes involved in thyroid hormone regulation on TSH and FT4 concentrations
RBTM Sterenborg, TE Galesloot… - The Journal of …, 2022 - academic.oup.com
Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
Thyroid hormones play key roles in cellular growth, development and metabolism. Although
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …
Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects
RP Peeters, H van Toor, W Klootwijk… - The Journal of …, 2003 - academic.oup.com
Single nucleotide polymorphisms (SNPs) in genes involved in thyroid hormone metabolism
may affect thyroid hormone bioactivity. We investigated the occurrence and possible effects …
may affect thyroid hormone bioactivity. We investigated the occurrence and possible effects …
Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone
Purpose Thyroid hormones are essential for the normal function of almost all human tissues,
and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3) …
and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3) …
Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network
Thyroid stimulating hormone (TSH) hormone levels are normally tightly regulated within an
individual; thus, relatively small variations may indicate thyroid disease. Genome-wide …
individual; thus, relatively small variations may indicate thyroid disease. Genome-wide …
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
E Porcu, M Medici, G Pistis, CB Volpato… - PLoS …, 2013 - journals.plos.org
Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …
abnormalities in thyroid function lead to common endocrine disorders affecting …
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
RBTM Sterenborg, I Steinbrenner, Y Li… - Nature …, 2024 - nature.com
To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents
TRH Nielsen, EVR Appel, M Svendstrup, JD Ohrt… - PLoS …, 2017 - journals.plos.org
Background Hypothyroidism is associated with obesity, and thyroid hormones are involved
in the regulation of body composition, including fat mass. Genome-wide association studies …
in the regulation of body composition, including fat mass. Genome-wide association studies …
Genetics of thyroid function
M Medici, TJ Visser, RP Peeters - Best practice & research Clinical …, 2017 - Elsevier
Recent studies show that subtle variations in thyroid function, including subclinical thyroid
dysfunction, and even variation in thyroid function within the normal range, are associated …
dysfunction, and even variation in thyroid function within the normal range, are associated …
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