Objective Exposure of neonatal macaques to the antiseizure medications phenobarbital and
midazolam (PbM) causes widespread apoptotic death of neurons and oligodendrocytes. We …

The immature brain is intrinsically hyperexcitable, a feature that, despite being crucial for
learning, synaptogenesis and neuronal plasticity, predisposes the neonate to seizures …

Seizures after neonatal hypoxia are difficult to treat. A recent antiepileptic safety and dose-
finding study examined phenobarbital plus bumetanide, but was stopped owing to apparent …

Seizures in neonates, mainly caused by hypoxic-ischemic encephalopathy, are thought to
be harmful to the brain. Phenobarbital remains the first line drug therapy for the treatment of …

Objective: The mechanisms whereby birth asphyxia leads to generation of seizures remain
unidentified. To study the possible role of brain pH changes, we used a rodent model that …

This article summarizes the recent medical literature regarding perinatal asphyxia with
respect to timing and mechanisms of injury for neonates who were clinically diagnosed with …

Seizures are an early sign of brain injury in newborns. These seizures are in most cases
repetitive or associated with asymptomatic electrographic seizures. Despite the relative …

Hypoxic-ischemic encephalopathy (HIE) is a major cause of perinatal mortality and
subsequent severe neurological sequelae. Mild hypothermia is a standard therapy for HIE …

Perinatal brain injury or neonatal encephalopathy (NE) is a state of disturbed neurological
function in neonates, caused by a number of different aetiologies. The most prominent cause …

Seizures are common in newborn infants with hypoxic-ischemic encephalopathy and are
highly associated with adverse neurodevelopmental outcomes. The impact of seizure …