THE explosion of knowledge of the mechanisms of hypoxic-ischaemic neuronal death to a
large extent has been based on the use of pharmacological probes to dissect pathways …

Objective. Markers currently used to identify infants at highest risk for perinatal
hypoxicischemic cerebral injury are insensitive in predicting the subsequent occurrence of …

Acute symptomatic seizures in the term newborn are often seen after perinatal brain injury.
Common etiologies include hypoxic-ischemic encephalopathy, ischemic stroke, intracranial …

Seizures are common during the neonatal period, often due to hypoxic–ischemic
encephalopathy and may contribute to acute brain injury and the subsequent development …

Barbiturates and benzodiazepines are GABA A-receptor agonists and potent antiseizure
medications. We reported that exposure of neonatal macaques to combination of …

Background Neonatal seizures are common, but the impact of neonatal seizures on long‐
term neurologic outcomes remains unclear. We addressed this question by analyzing data …

Acute exposure to nerve agents induces a peripheral cholinergic crisis and prolonged status
epilepticus (SE), causing death or long-term brain damage. To provide preclinical data …

There is currently no therapeutic intervention to stem neonatal brain injury after exposure to
hypoxia-ischemia (HI). Potential neuroprotective treatments that can be delivered postinsult …

Objective Very preterm‐born neonates (24–32 weeks of gestation) are exposed to stressful
and painful procedures during neonatal intensive care. Analgesic and sedation therapies …

Background: Although seizures are very common in neonates and are often the harbinger of
poor neurologic outcome, there is controversy regarding the degree of brain damage …