Perinatal asphyxia is associated with an increased risk of cerebral palsy and significant
mortality. We investigated the use of flunarizine, a calcium antagonist and MK-801, an …

Opinion statement Hypoxic-ischemic (HI) brain injury is the most common cause of
encephalopathy and seizures in term newborn infants. There is no single, valid test for birth …

Moderate to severe neonatal hypoxic ischemic encephalopathy remains an important cause
of infant death and childhood disability. Early and accurate diagnosis of encephalopathy is …

Background Seizures are common following perinatal asphyxia and may exacerbate
secondary neuronal injury by increasing cerebral metabolic demand, causing fluctuations in …

Perinatal asphyxia can lead to death and severe disability. Brain hypoxia-ischemia (HI)
injury is the major pathophysiology contributing to death and severe disability after perinatal …

In vitro studies suggest that glutamate receptor activation is important in the genesis of post-
hypoxic preterm brain injury, but there are limited data on post-hypoxic N-methyl-d-aspartate …

Hypoxic-Ischemic Encephalopathy (HIE) is the consequence of systemic asphyxia occurring
at birth. Twenty five percent of neonates with HIE develop severe and permanent …

Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

Introduction Neonatal hypoxia is a common cause of early-life seizures. Both hypoxia-
induced seizures (HS), and the drugs used to treat them (eg, phenobarbital, PB), have been …

Neonatal hypoxic–ischemic encephalopathy is a major cause of mortality and disability in
newborns and the only standard approach for treating this condition is therapeutic …