Mass spectrometry-based proteome profiling of extracellular vesicles and their roles in cancer biology

R Bandu, JW Oh, KP Kim - Experimental & molecular medicine, 2019 - nature.com
Over the past three decades, extracellular vesicles (EVs) have arisen as important mediators
of intercellular communication that are involved in the transmission of biological signals …

Extracellular vesicles, the cornerstone of next-generation cancer diagnosis?

J Weng, X Xiang, L Ding, ALA Wong, Q Zeng… - Seminars in cancer …, 2021 - Elsevier
Cancer has risen up to be a major cause of mortality worldwide over the past decades.
Despite advancements in cancer screening and diagnostics, a significant number of cancers …

Tumor‐derived extracellular vesicles as a novel source of protein biomarkers for cancer diagnosis and monitoring

O Ruhen, K Meehan - Proteomics, 2019 - Wiley Online Library
Abstract “Liquid biopsies” have received attention as a complementary tool for traditional
tissue biopsies that may enhance the spectrum of analysis for tumor‐derived factors. One …

Extracellular vesicles and their potential use in monitoring cancer progression and therapy: the contribution of proteomics

MC Cufaro, D Pieragostino, P Lanuti… - Journal of …, 2019 - Wiley Online Library
Extracellular Vesicles (EVs) are small membrane‐enclosed particles released by cells and
able to vehiculate information between them. The term EVs categorizes many and different …

Extracellular vesicle and particle biomarkers define multiple human cancers

A Hoshino, HS Kim, L Bojmar, KE Gyan, M Cioffi… - Cell, 2020 - cell.com
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer
detection. We investigated the proteomic profile of extracellular vesicles and particles …

Multiplexed profiling of biomarkers in extracellular vesicles for cancer diagnosis and therapy monitoring

S Zhou, Y Yang, Y Wu, S Liu - Analytica chimica acta, 2021 - Elsevier
Extracellular vesicles (EVs) are nanoscale vesicles secreted by normal and pathological
cells. The types and levels of surface proteins and internal nucleic acids in EVs are closely …

Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells

DS Choi, DY Choi, BS Hong, SC Jang… - Journal of …, 2012 - Taylor & Francis
Cancer cells actively release extracellular vesicles (EVs), including exosomes and
microvesicles, into surrounding tissues. These EVs play pleiotropic roles in cancer …

The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers

T Katsuda, N Kosaka, T Ochiya - Proteomics, 2014 - Wiley Online Library
Recent important progress in cancer biology was the identification of the significant roles
played by extracellular vesicles (EVs). EVs are secreted by a variety of mammalian cell …

Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics

S Kreimer, AM Belov, I Ghiran, SK Murthy… - Journal of proteome …, 2015 - ACS Publications
This review discusses extracellular vesicles (EVs), which are submicron-scale, anuclear,
phospholipid bilayer membrane enclosed vesicles that contain lipids, metabolites, proteins …

Focus on extracellular vesicles: new frontiers of cell-to-cell communication in cancer

C Ciardiello, L Cavallini, C Spinelli, J Yang… - International journal of …, 2016 - mdpi.com
Extracellular Vesicles (EVs) have received considerable attention in recent years, both as
mediators of intercellular communication pathways that lead to tumor progression, and as …