Chronic inflammation in intracranial aneurysm formation

T Aoki, M Fukuda, S Narumiya - Inflammation and Regeneration, 2013 - jstage.jst.go.jp
Intracranial aneurysm (IA) is a cerebrovascular disease usually affected the bifurcation sites
of intracranial arteries. IA is socially important because IA can develop a lethal subarachnoid …

Molecular basis for intracranial aneurysm formation

M Fukuda, T Aoki - Neurovascular Events After Subarachnoid Hemorrhage …, 2015 - Springer
Intracranial aneurysm (IA) is a socially important disease both because it has a high
prevalence and because of the severity of resultant subarachnoid hemorrhages after IA …

Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms

J Frösen, J Cebral, AM Robertson, T Aoki - Neurosurgical focus, 2019 - thejns.org
OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …

Hemodynamic and histopathological changes in the early phase of the development of an intracranial aneurysm

H Kataoka, T Yagi, T Ikedo, H Imai… - Neurologia medico …, 2020 - jstage.jst.go.jp
Hemodynamic stress and chronic inflammation are closely associated with the pathogenesis
of intracranial aneurysms (IAs). However, the hemodynamic and biological mechanisms …

[HTML][HTML] Hemodynamics in Intracranial Aneurysm Formation

H Koseki - 2024 - intechopen.com
Intracranial aneurysms (IAs) are dilated lesions of the arterial wall caused by a dysfunction
of the hemodynamic stress, leading to subarachnoid hemorrhage, which can be devastating …

Two diverse hemodynamic forces, a mechanical stretch and a high wall shear stress, determine intracranial aneurysm formation

H Koseki, H Miyata, S Shimo, N Ohno, K Mifune… - Translational Stroke …, 2020 - Springer
Intracranial aneurysm (IA) usually induced at a bifurcation site of intracranial arteries causes
a lethal subarachnoid hemorrhage. Currently, IA is considered as a macrophage-mediated …

[HTML][HTML] Inflammation and intracranial aneurysms: mechanisms of initiation, growth, and rupture

PS Amenta, E Valle, AS Dumont… - Neuroimmunology and …, 2015 - oaepublish.com
Outcomes following aneurysmal subarachnoid hemorrhage remain poor in many patients,
despite advances in microsurgical and endovascular management. Consequently …

Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

T Aoki, J Frȍsen, M Fukuda, K Bando, G Shioi… - Science …, 2017 - science.org
Intracranial aneurysms are common but are generally untreated, and their rupture can lead
to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid …

Biology of intracranial aneurysms: role of inflammation

N Chalouhi, MS Ali, PM Jabbour… - Journal of Cerebral …, 2012 - journals.sagepub.com
Intracranial aneurysms (IAs) linger as a potentially devastating clinical problem. Despite
intense investigation, our understanding of the mechanisms leading to aneurysm …

Hemodynamic force as a potential regulator of inflammation-mediated focal growth of saccular aneurysms in a rat model

K Shimizu, H Kataoka, H Imai… - … of Neuropathology & …, 2021 - academic.oup.com
Past studies have elucidated the crucial role of macrophage-mediated inflammation in the
growth of intracranial aneurysms (IAs), but the contributions of hemodynamics are unclear …