The regulation of self-renewal in human embryonic stem cells

S Avery, K Inniss, H Moore - Stem cells and development, 2006 - liebertpub.com
Human embryonic stem (hES) cells have the ability to self-renew while maintaining their
pluripotency. The ability of stem cells to self-renew expansively is essential in both …

Molecular mechanisms involved in self‐renewal and pluripotency of embryonic stem cells

N Liu, M Lu, X Tian, Z Han - Journal of cellular physiology, 2007 - Wiley Online Library
Embryonic stem cells (ES cells) are derived from inner cell mass (ICM). The self‐renewal
and pluripotency are the main specificities of ES cells, which are likely to reveal a deeper …

[HTML][HTML] Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells

M Rao - Developmental biology, 2004 - Elsevier
The past few years have seen remarkable progress in our understanding of embryonic stem
cell (ES cell) biology. The necessity of examining human ES cells in culture, coupled with …

Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network

G Huang, S Ye, X Zhou, D Liu, QL Ying - Cellular and molecular life …, 2015 - Springer
Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the
capacity to generate any type of cell in the body, and therefore not only hold great promise …

Propagation and maintenance of undifferentiated human embryonic stem cells

MS Bodnar, JJ Meneses, RT Rodriguez… - Stem cells and …, 2004 - liebertpub.com
Human embryonic stem (hES) cells, like other stem cells, have the capacity to self-renew
without differentiation. Although hES cells can be differentiated to many different tissue types …

Diverse mechanisms regulate stem cell self-renewal

AV Molofsky, R Pardal, SJ Morrison - Current opinion in cell biology, 2004 - Elsevier
To what extent are the pathways that regulate self-renewal conserved between stem cells at
different stages of development and in different tissues? Some pathways play a strikingly …

Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

KA Becker, PN Ghule, JA Therrien… - Journal of cellular …, 2006 - Wiley Online Library
Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency.
However, there is a critical paucity of fundamental parameters of human ES cell division. In …

Human embryonic stem cells are pre‐mitotically committed to self‐renewal and acquire a lengthened G1 phase upon lineage programming

KA Becker, JL Stein, JB Lian… - Journal of cellular …, 2010 - Wiley Online Library
Self‐renewal of human embryonic stem (hES) cells proceeds by a unique abbreviated cell
cycle with a shortened G1 phase and distinctions in molecular cell cycle regulatory …

Embryonic stem cells

A Biswas, R Hutchins - Stem cells and development, 2007 - liebertpub.com
Stem cells are unique cell populations with the ability to choose between self-renewal and
differentiation. Embryonic stem (ES) cells have the ability to form any fully differentiated cell …

Human embryonic stem cells: multilineage differentiation and mechanisms of self-renewal

JS Draper, V Fox - Archives of medical research, 2003 - Elsevier
Human ES (hES) cells are pluripotent stem cells isolated from the inner cell mass (ICM) of
blastocysts, with the theoretical capacity to differentiate in vitro to produce all somatic and …