Hepatic deficiency of S-adenosylmethionine (AdoMet) is a critical acquired metabolic
abnormality in alcoholic liver disease (ALD) and in many experimental models of …

Methionine is one of the nine essential amino acids for humans. Methionine is not only a key
constituent of proteins, but it is also needed as a precursor of S-adenosyl-L-methionine …

S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA
and histone methylation, tuning regulation of gene expression. Appropriate intracellular …

Methionine adenosyltransferase (MAT) is the enzyme that catalyzes the synthesis of S-
adenosylmethionine (AdoMet), the main donor of methyl groups in the cell. In mammals MAT …

Deletion of glycine N‐methyltransferase (GNMT), the main gene involved in liver S‐
adenosylmethionine (SAM) catabolism, leads to the hepatic accumulation of this molecule …

Proteome analysis of human hepatocellular carcinoma tissues was conducted using two‐
dimensional difference gel electrophoresis coupled with mass spectrometry. Paired samples …

In clinical research, a novel approach has emerged: some of the essential nutrients are
being used to treat pathologic conditions. Many of these nutrients, including methionine …

S‐Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad
of biological and biochemical events. Although it has been claimed that AdoMet itself has …

In mammalian liver, two intersecting pathways, remethylation and transsulfuration, compete
for homocysteine that has been formed from methionine. Remethylation of homocysteine …

Methionine metabolism plays a central role in methylation reactions, production of
glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by …