STUDY QUESTION Do embryos with different developmental competence exhibit different
DNA methylation profiles at the blastocyst stage? SUMMARY ANSWER We established …

Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic
development. However, it is unknown whether abnormal methylome reprogramming occurs …

Background Assisted reproductive technology (ART) might induce adverse pregnancy
outcomes and increase the risk of metabolic diseases in offspring'later life with unknown …

Background The timing of the first cell divisions may predict the developmental potential of
an embryo, including its ability to establish pregnancy. Besides differences related to …

DNA methylation is a key epigenetic mechanism responsible for gene regulation, chromatin
remodeling, and genome stability, playing a fundamental role during embryonic …

To explore the mechanisms leading to the poor quality of IVF blastocysts, the single-cell
whole-genome methylation sequencing technique was used in this study to analyse the …

The first cell differentiation in the mammalian development separates the trophoblast and
embryonic cell lineages, resulting in the formation of the trophectoderm (TE) and inner cell …

Background Aberrant DNA methylation patterns of genes required for development are
common in in vitro produced embryos. In this regard, we previously identified altered DNA …

Purpose We aimed to compare the DNA methylation profiles of human embryos cultured in
uninterrupted or interrupted incubators. Methods This study included 9 women,≤ 30 years …

DNA methylation undergoes drastic fluctuation during early mammalian embryogenesis.
The dynamics of global DNA methylation in bovine embryos, however, have mostly been …