Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel–
Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell …

Mutations in VHL underlie von Hippel–Lindau (VHL) disease, a hereditary cancer syndrome
with several subtypes depending on the risk of developing certain combination of classic …

The von Hippel–Lindau tumor suppressor protein (pVHL) is the substrate-recognition
module of an E3 ubiquitin ligase that targets the alpha subunits of hypoxia-inducible factor …

Mammalian cells sense changes in oxygen and transduce that information into adaptive
changes in gene expression using a conserved pathway that converges on the …

Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor
protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights …

Germ line VHL tumor suppressor gene loss-of-function mutations cause von Hippel-Lindau
disease, which is associated with an increased risk of central nervous system …

Biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is linked to the
development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as …

Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …

Abstract The von Hippel–Lindau tumor suppressor gene product, pVHL, functions as the
substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen …

Clear cell carcinoma of the kidney is a major cause of mortality in patients with von Hippel-
Lindau (VHL) disease, which is caused by germ line mutations that inactivate the VHL tumor …