For animals, epigenetic modifications can be globally or partially inherited from gametes
after fertilization, and such information is required for proper transcriptional regulation …

Background Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in
zebrafish and is a period of extensive chromatin remodeling. Genome-scale gametic …

Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To understand this process, we determined the DNA methylation (DNAme) …

The epigenome plays critical roles in controlling gene expression and development.
However, how the parental epigenomes transit to the zygotic epigenome in early …

DNA methylation and histone modifications are epigenetic marks implicated in the complex
regulation of vertebrate embryogenesis. The cross-talk between DNA methylation and …

In mature human sperm, genes of importance for embryo development (ie, transcription
factors) lack DNA methylation and bear nucleosomes with distinctive histone modifications …

Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …

Background Epigenetic processes are proposed to be a mechanism regulating gene
expression during phenotypic plasticity. However, environmentally induced changes in DNA …

DNA methylation is a dynamic process through which specific chromatin modifications can
be stably transmitted from parent to daughter cells. A large body of work has suggested that …

DNA accessibility of cis-regulatory elements (CREs) dictates transcriptional activity and
drives cell differentiation during development. While many genes regulating embryonic …