Stroke is one of the most devastating neurological disabilities and brain's vulnerability
towards it proves to be fatal and socio‐economic loss of millions of people worldwide …

Stroke represents one of the most common causes of brain's vulnerability for many millions
of people worldwide. The plethora of physiopathological events associated with brain …

Hemorrhagic stroke which consists of subarachnoid hemorrhage and intracerebral
hemorrhage is a dominant cause of death and disability worldwide. Although great efforts …

Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for the poor prognosis
of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic …

Melatonin is mainly produced in the mammalian pineal gland during the dark phase. Its
secretion from the pineal gland has been classically associated with circadian and circanual …

Melatonin (n-acetyl-5-methoxy-tryptamine), a naturally occurring indole produced mainly by
the pineal gland, is a well known antioxidant. Stroke (cerebral ischemia) is the second …

The brain is highly susceptible to focal or global ischemia. Unless ischemia is promptly
reversed, reperfusion produces further cerebral damage. Acute thrombolysis or …

Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen
species (ROS), which leads to the oxidation of cellular proteins, DNA, and lipids as an initial …

Abstract: The brain is deficient in oxidative defense mechanisms and hence is at greater risk
of damage mediated by reactive oxygen species (ROS) resulting in molecular and cellular …

This review summarizes the reports that have documented the neuroprotective effects of
melatonin against ischemia/reperfusion brain injury. The studies were carried out on several …