Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …
with important functional implications for gene regulation. So far little is known about the …
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation
DNA methylation is an essential epigenetic modification that plays a key role associated with
the regulation of gene expression during differentiation, but in disease states such as …
the regulation of gene expression during differentiation, but in disease states such as …
[HTML][HTML] An integrative analysis of DNA methylation and RNA-Seq data for human heart, kidney and liver
Background Many groups, including our own, have proposed the use of DNA methylation
profiles as biomarkers for various disease states. While much research has been done …
profiles as biomarkers for various disease states. While much research has been done …
Genome-scale DNA methylation maps of pluripotent and differentiated cells
DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …
[HTML][HTML] Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
Quantitative comparison of genome-wide DNA methylation mapping technologies
DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …
[HTML][HTML] Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development
Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …
are frequent events and play major roles regulating gene expression and other …
[HTML][HTML] Tackling the methylome: recent methodological advances in genome-wide methylation profiling
MRH Estécio, JPJ Issa - Genome medicine, 2009 - Springer
DNA methylation of promoter CpG islands is strongly associated with gene silencing and is
known as a frequent cause of loss of expression of tumor suppressor genes, as well as other …
known as a frequent cause of loss of expression of tumor suppressor genes, as well as other …
[HTML][HTML] Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer
Background There is growing evidence that DNA methylation alterations contribute to
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …
Genomic patterns and context specific interpretation of DNA methylation
T Baubec, D Schübeler - Current opinion in genetics & development, 2014 - Elsevier
Methylation of CpG dinucleotides is a reversible modification of DNA that is highly prevalent
throughout mammalian genomes. Recent advances generated genomic DNA methylation …
throughout mammalian genomes. Recent advances generated genomic DNA methylation …