Conservation and divergence of DNA methylation in eukaryotes: new insights from single base-resolution DNA methylomes
DNA methylation is one of the most important heritable epigenetic modifications of the
genome and is involved in the regulation of many cellular processes. Aberrant DNA …
genome and is involved in the regulation of many cellular processes. Aberrant DNA …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
The methylome: approaches for global DNA methylation profiling
S Beck, VK Rakyan - Trends in Genetics, 2008 - cell.com
DNA methylation plays a critical role in genome function both in health and disease. Almost
60 years after the discovery of 5-methyl cytosine and∼ 25 years since the discovery that …
60 years after the discovery of 5-methyl cytosine and∼ 25 years since the discovery that …
Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices
Y Xin, B Chanrion, MM Liu, H Galfalvy, R Costa… - PloS one, 2010 - journals.plos.org
Background Emerging evidence suggests that DNA methylation plays an expansive role in
the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of …
the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of …
Specific Methyl-CpG configurations define cell identity through gene expression regulation
T Improda, V Morgera, M Vitale, L Chiariotti… - International Journal of …, 2023 - mdpi.com
Cell identity is determined by the chromatin structure and profiles of gene expression, which
are dependent on chromatin accessibility and DNA methylation of the regions critical for …
are dependent on chromatin accessibility and DNA methylation of the regions critical for …
Spatiotemporal DNA methylome dynamics of the developing mammalian fetus
Genetic studies have revealed an essential role for cytosine DNA methylation in mammalian
development. However, its spatiotemporal distribution in the developing embryo remains …
development. However, its spatiotemporal distribution in the developing embryo remains …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
Human body epigenome maps reveal noncanonical DNA methylation variation
Understanding the diversity of human tissues is fundamental to disease and requires linking
genetic information, which is identical in most of an individual's cells, with epigenetic …
genetic information, which is identical in most of an individual's cells, with epigenetic …
MethBank 3.0: a database of DNA methylomes across a variety of species
Abstract MethBank (http://bigd. big. ac. cn/methbank) is a database that integrates high-
quality DNA methylomes across a variety of species and provides an interactive browser for …
quality DNA methylomes across a variety of species and provides an interactive browser for …
Mining cancer methylomes: prospects and challenges
There are over 28 million CpG sites in the human genome. Assessing the methylation status
of each of these sites will be required to understand fully the role of DNA methylation in …
of each of these sites will be required to understand fully the role of DNA methylation in …