Personalized epigenomic signatures that are stable over time and covary with body mass index
The epigenome consists of non–sequence-based modifications, such as DNA methylation,
that are heritable during cell division and that may affect normal phenotypes and …
that are heritable during cell division and that may affect normal phenotypes and …
[HTML][HTML] Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO
In mammals, DNA is methylated at CpG sites, which play pivotal roles in gene silencing and
chromatin organization. Furthermore, DNA methylation undergoes dynamic changes during …
chromatin organization. Furthermore, DNA methylation undergoes dynamic changes during …
[HTML][HTML] Genome-wide profiling of DNA methylation in human cancer cells
Global changes in DNA methylation correlate with altered gene expression and genomic
instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) …
instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) …
[HTML][HTML] DNA methylation profile dynamics of tissue-dependent and differentially methylated regions during mouse brain development
K Hirabayashi, K Shiota, S Yagi - BMC genomics, 2013 - Springer
Background Tissues and their component cells have unique DNA methylation profiles
comprising DNA methylation patterns of tissue-dependent and differentially methylated …
comprising DNA methylation patterns of tissue-dependent and differentially methylated …
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
Mouse has been extensively used as a model organism in many studies to characterize
biological pathways and drug effects and to mimic human diseases. Similar DNA sequences …
biological pathways and drug effects and to mimic human diseases. Similar DNA sequences …
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
DNA methylation stabilizes developmentally programmed gene expression states. Aberrant
methylation is associated with disease progression and is a common feature of cancer …
methylation is associated with disease progression and is a common feature of cancer …
[HTML][HTML] Comparative epigenomic profiling of the DNA methylome in mouse and zebrafish uncovers high interspecies divergence
The DNA methylation landscape is dynamically patterned during development and distinct
methylation patterns distinguish healthy from diseased cells. However, whether tissue …
methylation patterns distinguish healthy from diseased cells. However, whether tissue …
[HTML][HTML] Whole genome DNA methylation: beyond genes silencing
The combination of DNA bisulfite treatment with high-throughput sequencing technologies
has enabled investigation of genome-wide DNA methylation at near base pair level …
has enabled investigation of genome-wide DNA methylation at near base pair level …
Epigenetics: differential DNA methylation in mammalian somatic tissues
H Nagase, S Ghosh - The FEBS journal, 2008 - Wiley Online Library
Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …
CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression
R Chatterjee, C Vinson - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
CG methylation is an epigenetically inherited chemical modification of DNA found in plants
and animals. In mammals it is essential for accurate regulation of gene expression and …
and animals. In mammals it is essential for accurate regulation of gene expression and …