The TET (ten–eleven translocation) family of α-ketoglutarate (α-KG)-dependent
dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to 5 …

The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …

DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display …

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at
repressed genes in the host tissue, but the preceding events driving this phenomenon are …

Dysregulated DNA methylation followed by abnormal gene expression is an epigenetic
hallmark in cancer. DNA methylation is catalyzed by DNA methyltransferases, and the …

DNA methylation at the 5-position of cytosines (5mC) represents an important epigenetic
modification involved in tissue differentiation and is frequently altered in cancer. Recent …

DNA methylation is an important epigenetic modification and is frequently altered in cancer.
Convert of 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC) by ten-eleven …

Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–
eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild …

The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic
modification in mammalian genomes, and its abnormalities are intimately coupled to various …

DNA methylation is one of the critical epigenetic modifications regulating various cellular
processes such as differentiation or proliferation, and its dysregulation leads to disordered …