To produce chronic infection, microbial pathogens must escape host immune defenses.
Infection with the human pathogenic fungus Cryptococcus neoformans is typically chronic …

Cryptococcus neoformans (CN), an encapsulated, ubiquitous environmental yeast, is
pathogenic for humans, primarily those with compromised immune function. CN is believed …

Recently, we demonstrated that human monocyte-derived macrophages (MDM) treated with
chloroquine or ammonium chloride had markedly increased antifungal activity against the …

The pathogenesis of Cryptococcus neoformans pulmonary infection in the rat was studied
after intratracheal inoculation. Lungs were examined at various times following infection for …

The pathogenesis of Cryptococcus neoformans infection has been studied extensively with
respect to inflammatory and pathological changes, but very little information is available …

Cryptococcus neoformans was first described as a human fungal pathogen more than a
century ago. One aspect of the C. neoformans infectious life cycle that has been the subject …

Fungal pathogens are notorious for causing chronic and latent infections, but the
mechanism by which they evade the immune response is poorly understood. A major …

Few fungi are pathogenic to humans. Of these, Cryptococcus neoformans has emerged as
an important cause of mortality in immunocompromised patients, especially those with AIDS …

Upon ingestion by macrophages, Cryptococcus neoformans can survive and replicate
intracellularly unless the macrophages become classically activated. The mechanism …

Cryptococcus neoformans (Cn) is an encapsulated yeast that is a facultative intracellular
pathogen and a frequent cause of human disease. The interaction of Cn with alveolar …