DNA methylation disruption reshapes the hematopoietic differentiation landscape
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
Loss of Dnmt3a immortalizes hematopoietic stem cells in vivo
Somatic mutations in DNMT3A are recurrent events across a range of blood cancers.
Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self …
Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self …
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
SJ Kim, H Zhao, S Hardikar, AK Singh… - Blood, The Journal …, 2013 - ashpublications.org
Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …
frequently in acute myeloid leukemia and other hematological malignancies, with the …
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
M Yagi, M Kabata, A Tanaka, T Ukai, S Ohta… - Nature …, 2020 - nature.com
De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B.
Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) …
Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) …
Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells
Background DNA methylation patterns are initiated by de novo DNA methyltransferases
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …
[HTML][HTML] Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs
F Neri, A Krepelova, D Incarnato, M Maldotti, C Parlato… - Cell, 2013 - cell.com
The de novo DNA methyltransferase 3-like (Dnmt3L) is a catalytically inactive DNA
methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is …
methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is …
The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development
Abstract DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian
development. Two isoforms of DNMT3A are differentially expressed from stem cells to …
development. Two isoforms of DNMT3A are differentially expressed from stem cells to …
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability
K Tatton-Brown, S Seal, E Ruark, J Harmer… - Nature …, 2014 - nature.com
Overgrowth disorders are a heterogeneous group of conditions characterized by increased
growth parameters and other variable clinical features such as intellectual disability and …
growth parameters and other variable clinical features such as intellectual disability and …
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies
CB Cole, DA Russler-Germain, S Ketkar… - The Journal of …, 2017 - Am Soc Clin Investig
The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …
Divergent effects of Dnmt3a and Tet2 mutations on hematopoietic progenitor cell fitness
The DNA methylation regulators DNMT3A and TET2 are recurrently mutated in
hematological disorders. Despite possessing antagonistic biochemical activities, loss-of …
hematological disorders. Despite possessing antagonistic biochemical activities, loss-of …